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Hormonally Active Chemotherapy

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Hormonally Active Chemotherapy, Hormonal Antineoplastic Agent, Hormonal Therapy in Oncology, Hormone Therapy in Cancer, Cancer Hormonal Therapy

  • See Also
  1. Chemotherapy
  1. Background
    1. Naturally occurring Hormones or their derivatives
  2. Corticosteroids (lymphoid malignancy)
    1. Short-acting (e.g. Hydrocortisone)
    2. Intermediate-acting (e.g. Prednisone, Methylprednisolone)
    3. Long-acting (e.g. Dexamethasone)
  3. Somatostatin Analogs (GI neuroendocrine tumors, Carcinoid Syndrome, Merkel Cell carcinoma)
    1. Octreotide (Sandostatin)
    2. Lanreotide (Somatuline)
  4. Progestins
    1. Megestrol acetate
    2. Medroxyprogesterone acetate
  5. Conjugates (novel, hormonal agents conjugated to a cytotoxic agent)
    1. Estramustine (EmCyt)
      1. Estrogen conjugated to an alkylkating agent
      2. Selective accumulation of alkylating cytotoxic effects in Estrogen receptor positive tumor cells
      3. Used in Prostate Cancer
  6. Other Uncommonly used (or historically used) hormonal Chemotherapy agents
    1. Androgens (Historical use in Breast Cancer)
      1. Fluoxymesterone
      2. Danazol
    2. Estrogens (Uncommon use in Prostate Cancer)
      1. Diethylstilbesterol
  • Medications
  • Hormone Synthesis Inhibitors
  1. Gonadotropin-Releasing Hormone Agonists (Breast Cancer, Prostate Cancer)
    1. Leuprolide (Lupron)
    2. Goserelin (Zoladex)
    3. Histrelin (Vantas)
  2. Gonadotropin-Releasing Hormone Antagonists (Prostate Cancer)
    1. Degarelix (Firmagon)
    2. Relugolix (Orgovyx)
  3. Androgen Synthesis Inhibitor (Prostate Cancer)
    1. Abiraterone (Zytiga)
  4. Aromatase Inhibitors (Breast Cancer)
    1. Letrozole (Femara, reversible)
    2. Anastrozole (Arimidex, reversible)
    3. Exemestane (Aromasin, irreversible)
    4. Aminoglutethimide (Cytadren)
  • Medications
  • Hormone Receptor Inhibitors
  1. Selective Estrogen Receptor Modulators (SERMs, Breast Cancer)
    1. Tamoxifen
    2. Raloxifene
    3. Toremifene
    4. Fulvestrant
  2. Antiandrogens - Non-Steroidal Testosterone Receptor Antagonists - First Generation (Prostate Cancer)
    1. Flutamide (Eulexin)
    2. Bicalutamide (Casodex)
    3. Nilutamide (Nilandron)
  3. Antiandrogens - Non-Steroidal Testosterone Receptor Antagonists - Second Generation (Prostate Cancer)
    1. Apalutamide (Erleada)
    2. Darolutamide (Nubeqa)
    3. Enzalutamide (Xtandi)
    4. Proxalutamide
  • References
  1. Fairchild (2015) AJR Am J Roentgenol 204(6):W620-30 +PMID: 26001251 [PubMed]