Methylprednisolone

Methylprednisolone tablets 2 mg, 4 mg, 8 mg, 16 mg, 32 mg
Medrol Dose Pack (contains 21 tablets, each 4 mg in Blister pack with taper schedule over 7 days)
Methylprednisolone Sodium succinate IV Solution (Solu-Medrol)
1. Avoid in milk protein Hypersensitivity
2. Avoid Benzyl Alcohol containing solution for intrathecal use or newborns
Methylprednisolone Acetate IM Solution (Depo-Medrol)
1. Duration of IM Injection is variable (1-6 days)
2. Also used for Intra-articular Corticosteroid

Adult
1. Parenteral (Solu-Medrol) 10 to 125 mg (typically 60 mg) IV or IM every 4 to 12 hours
2. Oral (Medrol) 4 to 48 mg orally daily
3. Medrol Dose pack: tapers from max of 24 mg orally over 7 days
  1. Avoid Medrol dose pack (replace with Prednisone 30 mg orally daily for 5 to 6 days to have similar effect)
4. Depo-Medrol: 4 to 120 mg IM every 1 to 2 weeks
Child
1. Dose: 1-2 mg/kg/dose orally, IV or IM every 6 to 12 hours
2. Maximum: 125 mg/dose (typically up to 60 mg/dose)

Methylprednisolone (Solu-Medrol) 1 mg/kg/dose (up to 60 mg) IV every 6 hours (or 80 mg IV every 8 hours)

Multiple Sclerosis Flare
1. Initial 3 day course of Methylprednisolone IV or Oral (similar efficacy for oral dosing)
  1. Methylprednisolone 1000 mg orally daily (or in divided doses) for 3 days OR
  2. Methylprednisolone 1000 mg in 500 ml D5W infused over 4 to 6 hours each morning for 3 days
2. Next: Steroid Taper after first 3 days (examples only, dosing varies widely, consult neurology for local protocol)
  1. Methylprednisolone 500 mg daily IV or Oral for 3 days, then 250 mg daily IV or Oral for 3 days
Optic Neuritis
1. Methylprednisolone 250 mg IV every 6 hours (or 1 g daily) for 3 days
  1. Typically followed by oral Corticosteroid course