Parenteral Drug Delivery


Parenteral Drug Delivery, Injectable Drug Delivery Route, Injectable Medication Route, Injectable Route of Medication Delivery, Parenteral Route, Parenteral Injection, Parenteral

  • Definitions
  1. Parenteral Route
    1. Term Parenteral is derived from "around the intestinal tract" (i.e. bypassing the intestinal tract)
    2. Parenteral Routes are preferred for conditions in which rapid absorption and consistent drug levels are critical (e.g. Resuscitation, Sepsis)
    3. Parenteral Routes risk infection as well as pain of administration
  • Types
  1. Intravenous (IV)
    1. Rapid onset of action and consistent and predictable drug levels
    2. Requires sterile, soluble drugs and Intravenous Access
  2. Intramuscular (IM)
    1. See Intramuscular Injection
    2. Drugs (e.g. Epinephrine, Penicillin) injected into large Muscle regions (e.g. Shoulder, thigh, buttock) rely on local capillary absorption
    3. Absorption is dependent on formulations (slow absorption with lipid preparations, faster absorption with aqueous preparations)
  3. Subcutaneous (SQ or SC)
    1. See Subcutaneous Injection
    2. Drugs (e.g. Insulin, Morphine, Enoxaparin) are injected beneath the skin and absorbed via local capillaries