Lab
Pancytopenia
search
Pancytopenia
, Bicytopenia
See Also
Aplastic Anemia
Definition
Bicytopenia: decrease in two of three cell lines
May suggest Pancytopenia in development
Pancytopenia: decrease in all blood cell lines
Anemia
Leukocytopenia
Thrombocytopenia
Causes
Aplastic Anemia
Vitamin B12 Deficiency
Folate Deficiency
Systemic Lupus Erythematosus
Paroxysmal Nocturnal Hemoglobinuria
Severe infection
Brucellosis
Sarcoidosis
Pregnancy
Fanconi's Anemia
Primary
Bone Marrow
disorder
Multiple Myeloma
Metastatic cancer
Myelofibrosis
Osteopetrosis
Splenic disorder
Lymphoma
Gaucher Disease
Niemann-
Pick Disease
Splenomegaly
due to congestion
Kala-Azar
Signs
Clinical Clues
Splenomegaly
Lymphadenopathy
Labs
Complete Blood Count
Pancytopenia consistent with cell counts as below
Peripheral Smear
Macrocytic Anemia
Reticulocytopenia
(
Reticulocyte Index
<1%)
Thrombocytopenia
(
Platelet Count
<20,000/mm3)
Neutropenia
Absolute Neutrophil Count
<500/mm3
ANC <200/mm3 suggests very severe disease
Evaluation
Bone Marrow Biopsy
: Normal count or hyperplasia
Findings: Blasts, Dysplasia or Fibrosis
Examples (See causes above)
Myelodysplastic Syndrome
Acute Myeloid Leukemia
(AML)
Agnogenic myeloid metaplasia
Bone Marrow Biopsy
: Fat infiltration (Hypoplasia)
Acquired
Aplastic Anemia
or
Fanconi's Anemia
Diepoxybutane induced
Chromosome
breakage or
Mitomycin
-C induced
Chromosome
breakage
References
Lee (1999) Wintrobe's Hematology, Lippincott, p. 1449
Saiki in Friedman (1991) Medical Diagnosis, p. 225
Type your search phrase here