Pharm

Tradipitant

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Tradipitant, Nereus

  • See Also
  1. Motion Sickness
  2. Neurokinin-1 Receptor Antagonist
  • Indications
  1. Prevention of Motion-Induced Vomiting (Motion Sickness)
  • Mechanism
  1. See Neurokinin-1 Receptor Antagonist
  2. Blocks the neurokinin-1 receptor (a tachykinin)
  3. Crosses the blood brain barrier to inhibit CNS Substance-P activity, reducing Motion-Induced Vomiting
  • Dosing
  1. Tradipitant 85-170 mg orally 60 minutes before triggering event (e.g. boating)
  2. Take on an empty Stomach
  3. Do not repeat dosing for 24 hours
  • Efficacy
  1. Decreases Vomiting (NNT 4)
    1. However, minimal effect on motion-induced Nausea
  • Adverse Effects
  1. Minimal sedation (contrast with Antihistamines such as Meclizine)
  2. Expensive (in 2026, each 85 capsule costs $255)
  • Drug Interactions
  1. Strong CYP3A4 Inhibitors (e.g. Clarithromycin)
    1. Increases Tradipitant adverse effects
  • Resources
  1. Tradipitant (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a021ebd-16ac-4354-b4b2-1c3950c091e5
  • References
  1. (2026) Presc Lett 33(6): 5-6