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Meclizine

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Meclizine, Antivert, Bonine, Medivert, Meclicot

  • See Also
  1. Antihistamine
  2. Anticholinergic Toxicity
  3. Vertigo Management
  4. Motion Sickness
  5. Dimenhydrinate
  • Indications
  1. Vertigo
  2. Motion Sickness
  • Mechanism
  1. See Antihistamine
  2. H1 Receptor Antagonist (First Generation Antihistamine)
  3. Meclizine is a synthetic piperazine derivative with Antihistamine (moderate Anticholinergic) and Antiemetic activity
  • Precautions
  1. Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
    1. Deaths have occurred in younger children related to Anticholinergic Toxicity
  • Dosing
  1. Approved for age >=12 years
  2. Vertigo (not FDA approved)
    1. Dose 25 mg orally four times daily as needed
  3. Motion Sickness
    1. Start: 25 to 50 mg orally 1 hour prior to travel
    2. Next: 25 to 50 mg orally daily during travel
  • Adverse Effects
  1. See Antihistamine
  2. See Anticholinergic Toxicity
  3. Sedation
  • Safety
  1. Pregnancy category B
  2. Unknown safety in Lactation
  • Resources
  1. Meclizine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=666dc4d8-7b16-4c3c-84e4-645548dbee68
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia