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Reactive Infectious Mucocutaneous Eruption

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Reactive Infectious Mucocutaneous Eruption, RIME

  • See Also
  1. Cutaneous Conditions in Febrile Patients
  2. Mucositis
  3. Oral Ulcer
  • Definitions
  1. Reactive Infectious Mucocutaneous Eruption (RIME)
    1. Mucocutaneous eruption after a viral or Bacterial respiratory tract infection
  • Epidemiology
  1. Most common in children and teens following respiratory tract infection
  • Causes
  1. Mycoplasma pneumoniae (original associated, preceding infection)
  2. Adenovirus
  3. Chlamydia pneumoniae
  4. Influenza
  • Signs
  1. Mucosal lesions (most common)
  2. Cutaneous lesions (less common)
    1. Macules and Papules
    2. Bullous lesions or target lesions suggest alternative diagnosis (e.g. Erythema Multiforme)
  • Diagnosis
  1. Two or more mucosal sites demonstrating lesions AND
  2. Cutaneous sites (if present) affect <10% of skin surface area
  • Differential Diagnosis
  1. See Mucositis
  2. See Oral Ulcer
  • Management
  1. Self-limited and mild manifestations
  2. Supportive care
  • References
  1. Canavan (2015) J Am Acad Dermatol 72(2):239-45 +PMID: 25592340 [PubMed]
  2. Gámez-González (2021) Pediatr Dermatol 38(1):306-8 +PMID: 33063905 [PubMed]
  3. HIrai (2023) Am Fam Physician 108(5): 509-10 [PubMed]
  4. Ramien (2020) JAMA Dermatol 156(2):124-5 +PMID: 31851301 [PubMed]