Impotence
Erectile Dysfunction Causes
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Erectile Dysfunction Causes
, Impotence Causes, Erectile Dysfunction Risk Factors
Causes
Endocrine
Diabetes Mellitus
(most common)
Impotence
occurs in 50% of men with
Diabetes Mellitus
Abnormal
Glucose
tolerance in 15% men with
Impotence
(ED may be an indicator sign for undiagnosed DM)
Confers 3 fold increased
Erectile Dysfunction
(esp. with longer duration of
Diabetes Mellitus
)
Metabolic Syndrome
and
Obesity
Low
Serum Testosterone
Excessive aromatase (in adipose) converts
Testosterone
to
Estradiol
Confers 2.6 fold increased
Erectile Dysfunction
(esp. with higher
Fastin
g
Glucose
)
Hypogonadism
(5% of
Impotence
cases)
Hyperprolactinemia
(
Prolactinoma
)
Hypothyroidism
(6% of
Impotence
cases)
Hyperthyroidism
Cushing's Syndrome
Causes
Vascular
Coronary Artery Disease
Shares similar risks for
Erectile Dysfunction
Erectile Dysfunction
is diagnosed 2-5 years before
Coronary Artery Disease
Potential for lifestyle intervention to prevent progression to symptomatic CAD (esp. ages 40-49 yo)
Also associated with a 75% increased risk of
Peripheral Vascular Disease
Peripheral Vascular Disease
Chronic Renal Failure
Hypertension
Hyperlipidemia
Causes
Neurologic disease
Multiple Sclerosis
Alzheimer Disease
Parkinson Disease
Cerebrovascular Accident
Spinal Cord Injury
(50%
Impotence
risk)
Paraplegia
Quadriplegia
Pelvic irradiation
Pelvic Surgery
Simple
Prostate
ctomy: 10%
Impotence
risk
Radical Prostatectomy
: 40%
Impotence
risk
Causes
Medications
See
Medication Causes of Impotence
Causes
Habit Related
Substance Abuse
Alcoholism
(associated with
Hypogonadism
)
Anabolic Steroid
s
Heroin
Marijuana
Methamphetamine
Cocaine
Tobacco Abuse
Penile artery clot in 72% of men with 20 pack years
Erectile Dysfunction
risk increased 51% in current smokers and 20% of ex-smokers compared with non-smokers
Cao (2013) PLoS One 8(4): e60443 [PubMed]
Causes
Miscellaneous
Advanced age
Obesity
Peyronie Disease
Psychogenic causes (20% of
Impotence
cases)
Anxiety Disorder
Major Depression
Relationship problems
References
Heidelbaugh (2010) Am Fam Physician 81(3): 305-12 [PubMed]
McVary (2007) N Engl J Med 357(24): 2472-81 [PubMed]
Rew (2016) Am Fam Physician 94(10): 820-7 [PubMed]
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