Diffuse

Antisynthetase syndrome

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Antisynthetase syndrome, Anti-synthetase Syndrome

  • See Also
  1. Polymyositis
  2. Dermatomyositis
  • Pathophysiology
  1. Cross-over syndrome of Polymyositis or Dermatomyositis with other Connective Tissue Disorders
  • Signs
  1. Fever
  2. Nonerosive Arthritis
  3. Raynaud Phenomenon
  4. Interstitial Lung Disease
  5. Distal Fingertip fissures (mechanic's hands)
  • Labs
  1. See Polymyositis and Dermatomyositis
  2. Screening
    1. Antinuclear Antibody
  3. Confirmation
    1. Myositis specific antibodies (of which Anti-Jo-1 Antibody is most sensitive) are only positive in 20% of cases
  • References
  1. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]