Lab

Immunoglobulin E

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Immunoglobulin E, IgE Immunoglobulin, Gamma Globulin E, IgE

  • Lab
  • Normal
  1. Range: <25 ug/dl
  2. Varies by age
  • Physiology
  1. Long stem (Fc) monomeric Antibody with Molecular weight 180,000 dalton
  2. Serum Half-Life of 2.5 days
  3. Reacts to allergans (Type 1 Hypersensitivity) and Parasitic Infections
  • Causes
  • Decreased
  1. Congenital Hypogammaglobulinemia
  2. Acquired Hypogammaglobulinemia
  3. Sex-linked Hypogammaglobulinemia
  4. Ataxia-Telangiectasia
  5. IgE Deficiency
  • Causes
  • Increased
  1. Allergic disorders
    1. Asthma
    2. Allergic Rhinitis or Hayfever
    3. Inhalant allergy
    4. Atopic Rhinitis or Sinusitis
    5. Atopic Dermatitis
    6. Urticaria
    7. Bronchopulmonary Aspergillus
    8. Hypersensitivity pneumonitis
    9. Drug Allergy
    10. Food Allergy
  2. Parasitic Infection
    1. Ascariasis
    2. Visceral Larva Migrans
    3. Toxocara
    4. Capillariasis
    5. Echinococcosis
    6. Hookworm (Necator)
    7. Amebiasis
  3. Immunologic disorders
    1. Hyper-IgE, Recurrent Pyoderma (Job-Buckley Syndrome)
    2. Thymic dysplasia or deficiency
    3. Wiskott-Aldrich Syndrome
    4. Pemphigoid
    5. Periarteritis Nodosa
    6. Hypereosinophilic Syndrome
  4. Neoplasm (i.e. IgE Myeloma)
  • References
  1. Bakerman (1984) ABCs of Lab Data, p. 252-3