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Hib Vaccine

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Hib Vaccine, Haemophilus influenzae B Vaccine, ActHIB, Hiberix, PedvaxHIB

  • Mechanism
  1. Conjugated protein Vaccine
  • Preparations
  1. Individual Vaccinations
    1. PRP-T (ActHIB or Hiberix)
    2. PRP-OMP (PedvaxHIB)
      1. Stronger immune response with first dose
      2. Preferred in high risk communities
        1. American Indian or Alaska native
        2. Asplenia or Immunosuppression
  2. Standard Combination agents (most common delivery for U.S. Primary Series)
    1. DTaP/IPV/PRP-T (Pentacel)
    2. PRP-OMP/HepB (Comvax)
  3. Other combinations (limited use)
    1. Hib/MenCY (Menhibrix)
  1. Dose 1: Age 2 months
  2. Dose 2: Age 4 months
  3. Dose 3: Age 6 months (dose 3 is skipped if using PedvaxHIB for all other 3 doses)
  4. Dose 4: Age 12 to 15 months
  • Efficacy
  1. Decreased Incidence by 99% since Hib Vaccination began in 1989
    1. Previously Hib was most common cause of Meningitis and invasive disease <5 years old
  • Adverse Effects
  1. No serious side effects
  2. Fever
  3. Irritability
  4. References
    1. (1996) MMWR Morb Mortal Wkly Rep 45(No. RR-12):1-35 [PubMed]
  1. Immunocompromised state requires additional Hib doses (esp. if age 12 to 59 months)
    1. https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html#note-hib
  2. Conditions required additional Hib Vaccine doses (see CDC guidelines)
    1. Chemotherapy or Radiation Therapy
    2. Hematopoietic Stem Cell Transplant
    3. Anatomic Asplenia or Functional Asplenia (e.g. Sickle Cell Anemia)
    4. Elective Splenectomy
    5. HIV Infection
    6. Immunoglobulin Deficiency or Early component complement deficiency
  • Resources
  1. CDC Immunization Schedules (last accessed 10/28/2020)
    1. https://www.cdc.gov/vaccines/schedules/
  • References
  1. Ackerman (2015) Am Fam Physician 92(6): 460-8 [PubMed]
  2. Briere (2014) MMWR Recomm Rep 63(RR-01):1-14 [PubMed]