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Yasmin

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Yasmin, Drosperinone, Yaz, Yasminelle, Ocella, Zarah, Nextstellis

  • See Also
  1. Oral Contraceptive
  2. Progestin
  • Indications
  1. Contraception
  • Contraindications
  1. Renal Insufficiency
  2. Hepatic insufficiency
  3. Adrenal Insufficiency
  • Mechanism
  • Drosperinone
  1. Newer synthetic Progestin
  2. Antiandrogenic activity similar to Progesterone
  3. Lowest Androgenic Activity
    1. Marginal benefit over other low androgen OCPs
  4. Antimineralcorticoid effect (Related to Spironolactone)
    1. Only OCP Progestin with antimineralcorticoid activity
    2. Drospirenone 3 mg is equivalent to 25 mg Spironolactone
  • Efficacy
  1. Similar to other Oral Contraceptives
  • Formulations
  1. Yaz
    1. Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
    2. Taken for 24 active days and 4 Placebo days
  2. Yasminelle
    1. Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
    2. Taken for 21 active days and 7 Placebo days
  3. Yasmin, Ocella or Zarah
    1. Contains 3 mg drospirenone and 30 mcg Ethinyl Estradiol
  4. Nextstellis
    1. Contains 3 mg drospirenone and 14.2 mg Estetrol (in mg, NOT mcg)
    2. Taken for 24 active days and 4 Placebo days
    3. At time of release in 2021, very expensive (approaching $200/month compared with <$10 for generics)
    4. Estetrol is a new plant-derived Estrogen (E4) formulation
      1. Based on NEST (Native Estrogen with Selective Actions in Tissues)
      2. Carries same Estrogen-related effects and contraindications
    5. References
      1. (2021) Presc Lett 28(7): 38
  • Drug Interactions
  • Potassium retention effects
  1. Potassium sparing Diuretics (e.g. Spironolactone)
  2. ACE Inhibitors
  3. Angiotensin Receptor Blockers
  4. Aldosterone Antagonists
  5. Heparin
  6. Nonsteroidal Anti-inflammatory drugs
  1. Indicated if concurrent use of drugs listed above
  • Adverse Effects
  1. See Oral Contraceptive
  2. Potassium retention (see above)
  3. May be associated with higher Thromboembolism risk
  • Advantages
  1. May be associated with less weight gain than other OCP
  2. As effective as other OCPs in Acne Vulgaris
  3. May be useful in Polycystic Ovary Disease
    1. Spironolactone used for associated Hirsutism
  • References
  1. (2002) Med Lett Drugs Ther 44(1133):55-7 [PubMed]