- Renal Insufficiency
- Hepatic insufficiency
- Adrenal Insufficiency
- Drosperinone
- Newer synthetic Progestin
- Antiandrogenic activity similar to Progesterone
- Lowest Androgenic Activity
- Marginal benefit over other low androgen OCPs
- Antimineralcorticoid effect (Related to Spironolactone)
- Only OCP Progestin with antimineralcorticoid activity
- Drospirenone 3 mg is equivalent to 25 mg Spironolactone
- Similar to other Oral Contraceptives
- Yaz
- Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
- Taken for 24 active days and 4 Placebo days
- Yasminelle
- Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
- Taken for 21 active days and 7 Placebo days
- Yasmin, Ocella or Zarah
- Contains 3 mg drospirenone and 30 mcg Ethinyl Estradiol
- Nextstellis
- Contains 3 mg drospirenone and 14.2 mg Estetrol (in mg, NOT mcg)
- Taken for 24 active days and 4 Placebo days
- At time of release in 2021, very expensive (approaching $200/month compared with <$10 for generics)
- Estetrol is a new plant-derived Estrogen (E4) formulation
- Based on NEST (Native Estrogen with Selective Actions in Tissues)
- Carries same Estrogen-related effects and contraindications
- References
- (2021) Presc Lett 28(7): 38
- Potassium retention effects
- Serum Potassium in first month
- Indicated if concurrent use of drugs listed above
- See Oral Contraceptive
- Potassium retention (see above)
- May be associated with higher Thromboembolism risk
- May be associated with less weight gain than other OCP
- As effective as other OCPs in Acne Vulgaris
- May be useful in Polycystic Ovary Disease
- Spironolactone used for associated Hirsutism