Endo

HAIR-AN Syndrome

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HAIR-AN Syndrome

  • Definition
  • Hair-AN Acronym
  • Pathophysiology
  1. Primary abnormality
    1. Insulin Resistance causes increased Insulin
  2. Secondary abnormality
    1. Excess androgen secretion from ovaries
  • Management
  1. General Measures
    1. Weight loss
    2. See Hirsutism
  2. Gonadotropin suppression
    1. Oral Contraceptives (low Androgenic Activity)
      1. Desogestrel (Desogen)
      2. Norgestimate (Ortho-Cyclen)
    2. Anti-androgens
      1. Spironolactone (Aldactone) 50 to 100 mg po bid
      2. Flutamide (Eulexin)
        1. Risk of hepatotoxicity
      3. Finasteride (Proscar) 5 mg per day
  3. Insulin Resistance Modifier
    1. Glucophage (Metformin) 500 - 850 mg PO qd to bid