Pituitary

Acromegaly

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Acromegaly

  • See Also
  1. Gigantism
  • Pathophysiology
  1. Pituitary Adenoma hypersecretion of Growth Hormone
  2. Occurs after closure of epiphyses
  • Causes
  1. Hyperplastic Pituitary Adenoma
  2. Eosinophilic Pituitary Adenoma
  • Symptoms
  1. Headache
  2. Vision Loss
  3. Muscular weakness
  4. Back pain
  5. Limb pain
  6. Sweating
  7. Amenorrhea
  8. Polydipsia
  9. Polyuria
  • Signs
  1. Exaggerated supraorbital ridges
  2. Exophthalmos
  3. Enlargement of:
    1. Hands and Feet
    2. Mandible (separation of teeth)
    3. Nose, Lips and Tongue
  4. Bitemporal Hemianopsia to blindness
  5. Weight gain
  6. Hypertension
  7. Cardiomegaly
  8. Hepatomegaly
  9. Hypertrichosis
  10. Hyperthyroidism
    1. Goiter
    2. Thyrotoxicosis
  11. Diabetes Insipidus
  • Radiology
  1. Overgrowth of cancellous bone
  2. Osteoporosis
  3. Tufted phalangeal tips
  4. Osteoarthritis signs
  5. Enlarged sella turcica
  • Labs
  1. Elevated plasma Growth Hormone (in active stage)
  2. Increased urinary 17-ketosteroids
  3. High serum inorganic Phosphate
  4. Elevated Alkaline Phosphatase
  5. Hyperglycemia
  6. Glycosuria
  • Management
  1. Transphenoidal surgery
  2. Radiation Therapy
  3. Bromocriptine