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Rabeprazole

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Rabeprazole, Aciphex

  • See Also
  1. Proton Pump Inhibitor
  2. Omeprazole
  3. Lansoprazole
  4. Esomeprazole
  5. Pantoprazole
  6. Dexlansoprazole
  • Indications
  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome
  • Contraindications
  1. Hypersensitivity to Proton Pump Inhibitors
  2. Use with caution in severe liver disease
  • Dosing
  • Adult
  1. See Helicobacter Pylori Treatment
  2. Background
    1. May take regardless of food timing
    2. When using for Helicobacter Pylori, take with meals
  3. Gastroesophageal Reflux
    1. Take 20 mg orally daily for 4 to 16 weeks
  4. Duodenal Ulcer
    1. Take 20 mg orally daily for 4 weeks
  5. Zollinger Ellison Syndrome
    1. Take 60 mg orally daily (up to twice daily)
  • Dosing
  • Child
  1. Age 1 to 11 years
    1. Weight <15 kg: Give 5 mg orally once daily (maximum 10 mg/day) for up to 8 weeks
    2. Weight >15 kg: Give 10 mg orally once daily for up to 8 weeks
  2. Age >=12 years
    1. Give 20 mg orally daily for up to 8 weeks
  • Pharmacokinetics
  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19 and CYP3A4
  • Mechanism
  1. See Proton Pump Inhibitor
  • Adverse Effects
  1. See Proton Pump Inhibitor
  • Precautions
  1. See Proton Pump Inhibitor
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in Lactation
  • Efficacy
  1. See Proton Pump Inhibitor
  • Drug Interactions
  1. See Proton Pump Inhibitor
  • Resources
  1. Rabeprazole (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=14412af6-e99c-4264-bc34-28a6f139f252
  • References
  1. (2022) Comparison of Proton Pump Inhibitors, Presc Lett, #380327
  2. (2012) Prescr Lett 19(3): 14 [PubMed]
  3. (2013) Prescr Lett 20(5): 30 [PubMed]
  4. (2001) Med Lett Drugs Ther 43(1103):36-7 [PubMed]
  5. Ament (2012) Am Fam Physician 86(1): 66-70 [PubMed]
  6. Vanderhoff (2002) Am Fam Physician 66(2):273-80 [PubMed]