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Pantoprazole

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Pantoprazole, Protonix

  • See Also
  1. Proton Pump Inhibitor
  2. Omeprazole
  3. Lansoprazole
  4. Esomeprazole
  5. Rabeprazole
  6. Dexlansoprazole
  • Indications
  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome
  • Contraindications
  1. Hypersensitivity to Proton Pump Inhibitors
  2. Use with caution in severe liver disease
  • Dosing
  • Adult
  1. See Helicobacter Pylori Treatment
  2. Background
    1. Take suspension 30 minutes prior to a meal
      1. Tablets may be taken regardless of food intake
    2. Suspension may be given via NG tube or G-Tube
    3. Intravenous dosing available
  3. Duodenal Ulcer or erosive Esophagitis
    1. Take 40 mg orally daily
  4. Zollinger Ellison Syndrome
    1. Take 40 mg orally twice daily OR
    2. Administer 80 mg IV every 8 to 12 hours until taking oral medications
  • Dosing
  • Child
  1. Indicated in GERD with erosive eosphagitis
  2. Weight <15 kg (off-label)
    1. Give 0.5 to 1 mg/kg/day
  3. Weight 15 to 40 kg
    1. Give 20 mg orally daily for up to 8 weeks
  4. Weight >=40 kg
    1. Give 40 mg orally daily for up to 8 weeks
  • Pharmacokinetics
  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19
  • Mechanism
  1. See Proton Pump Inhibitor
  • Adverse Effects
  1. See Proton Pump Inhibitor
  • Precautions
  1. See Proton Pump Inhibitor
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in Lactation
  • Efficacy
  1. See Proton Pump Inhibitor
  • Drug Interactions
  1. See Proton Pump Inhibitor
  • Resources
  1. Pantoprazole (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6b5ed424-2203-482f-bb85-2c97d9c356f2
  • References
  1. (2022) Comparison of Proton Pump Inhibitors, Presc Lett, #380327
  2. (2012) Prescr Lett 19(3): 14 [PubMed]
  3. (2013) Prescr Lett 20(5): 30 [PubMed]
  4. (2001) Med Lett Drugs Ther 43(1103):36-7 [PubMed]
  5. Ament (2012) Am Fam Physician 86(1): 66-70 [PubMed]
  6. Vanderhoff (2002) Am Fam Physician 66(2):273-80 [PubMed]