Pharm

Dexlansoprazole

search

Dexlansoprazole, Dexilant

  • See Also
  1. Proton Pump Inhibitor
  2. Omeprazole
  3. Lansoprazole
  4. Esomeprazole
  5. Pantoprazole
  6. Rabeprazole
  • Indications
  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome
  • Contraindications
  1. Hypersensitivity to Proton Pump Inhibitors
  2. Severe liver disease
    1. Limit maximum dose to 30 mg/day in moderate liver Impairment
  • Medications
  1. Dexlansoprazole (Dexilant) is the active L-Isomer of Lansoprazole (Prevacid)
  • Dosing
  1. Background
    1. Take regardless of timing of meal
    2. May open capsule and sprinkle on applesauce or water (may be given via NG tube)
    3. See Proton Pump Inhibitor for Discontinuation or Deprescribing
    4. Generic, but not OTC as of 2022
  2. Adults and age >=12 years
    1. Symptomatic Nonerosive Gastroesophageal Reflux
      1. Take 30 mg orally daily
    2. Erosive Esophagitis
      1. Take 60 mg orally daily for up to 8 weeks, then 30 mg orally daily for up to 6 months
  • Pharmacokinetics
  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19 and CYP3A4
  • Mechanism
  1. See Proton Pump Inhibitor
  • Adverse Effects
  1. See Proton Pump Inhibitor
  • Precautions
  1. See Proton Pump Inhibitor
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in Lactation
  • Efficacy
  1. See Proton Pump Inhibitor
  • Drug Interactions
  1. See Proton Pump Inhibitor
  • Resources
  1. Dexlansoprazole (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9819f033-3bbe-442e-8e92-45fec77b237d
  • References
  1. (2022) Comparison of Proton Pump Inhibitors, Presc Lett, #380327
  2. (2012) Prescr Lett 19(3): 14 [PubMed]
  3. (2013) Prescr Lett 20(5): 30 [PubMed]
  4. (2001) Med Lett Drugs Ther 43(1103):36-7 [PubMed]
  5. Ament (2012) Am Fam Physician 86(1): 66-70 [PubMed]
  6. Vanderhoff (2002) Am Fam Physician 66(2):273-80 [PubMed]