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Diarrhea Secondary to Medications

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Diarrhea Secondary to Medications, Drug-Induced Diarrhea, Medication-Induced Diarrhea, Medication Causes of Diarrhea

  • See Also
  1. Chronic Diarrhea
  2. Chronic Watery Diarrhea
  3. Acute Diarrhea
  4. Clostridium difficile
  1. Antibiotic Associated Diarrhea
    1. See Clostridium difficile
    2. Macrolides (e.g. Erythromycin)
    3. Aminoglycosides
    4. Amoxicillan-Clavulanate (Augmentin)
  2. Chemotherapeutic agents
  3. Antiinflammatory medications
    1. NSAIDS
    2. Colchicine
    3. Ticlopidine
  4. Antiarrhythmics
    1. Quinidine
    2. Digitalis (Digoxin)
  5. Antihypertensives
    1. Beta Blockers
    2. ACE Inhibitors
    3. Olmesartan (Benicar)
      1. May cause a sprue-like Enteropathy not seen with other Angiotensin Receptor Blockers
  6. Endocrine agents
    1. Acarbose (Precose)
    2. Orlistat (Xenical)
    3. Metformin (Glucophage)
    4. Thyroid Replacement
  7. Gastrointestinal Agents
    1. Magnesium Supplements
    2. Calcium containing Antacids
    3. Stimulant Laxatives (e.g. Bisacodyl, senna)
    4. H2 Receptor Antagonists (e.g. Ranitidine)
    5. Proton Pump Inhibitors (e.g. Omeprazole)
    6. Metoclopramide (Reglan)
  8. Miscellaneous agents
    1. Misoprostol
    2. Theophylline
    3. Calcitonin
    4. Lithium
    5. Selective Serotonin Reuptake Inhibitors (e.g. Sertraline)
  1. Magnesium containing preparations (Antacids, Laxatives)
  2. Citrates
  3. Phosphates
  4. Sulfates
  5. Sugar Alcohols
    1. Mannitol
    2. Sorbitol
    3. Xylitol
  1. Antiarrhythmics (Quinidine, Digoxin)
  2. Amoxicillan-Clavulanate (Augmentin)
  3. Chemotherapeutic agents
  4. Metformin (Glucophage)
  5. Calcitonin
  6. Colchicine
  7. NSAIDs
  8. Misoprostol
  • Causes
  • Increased Motility
  1. Macrolides (e.g. Erythromycin)
  2. Metoclopramide (Reglan)
  3. Stimulant Laxatives (e.g. Bisacodyl, senna)
  • Causes
  • Malabsorption
  1. Acarbose (Precose)
  2. Aminoglycosides
  3. Orlistat (Xenical)
  4. Thyroid Replacement
  • References
  1. Schiller in Feldman (2002) Sleisenger GI, p. 136
  2. Burgers (2020) Am Fam Physician 101(8): 472-80 [PubMed]