Pharm
Insulin Secretagogue
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Insulin Secretagogue
, Sulfonylurea
See Also
Oral Hypoglycemic
Agents
Background
Sulfonylureas
Sulfonylureas were first discovered in 1940's while investigating
Sulfonamide
antibiotics
First Generation Sulfonylurea
s (e.g.
Tolbutamide
) were developed in the 1960s
Second Generation Sulfonylurea
s were available in the 1980s
Sulfonylureas are also used as herbicides (block specific plant
Amino Acid
biosynthesis)
Meglitinide
s
Meglitinide
development started in the 1970s and were marketed in the U.S. in the late 1990s
Mechanism
Sulfonylureas stimulate
Potassium
channel closure on pancreatic beta cell surface
Triggers
Insulin
release
Medications
First Generation Sulfonylurea
(Listed for historical purposes only)
Second Generation Sulfonylurea
(e.g.
Glipizide
,
Glyburide
)
Non-Sulfonylurea Insulin Secretagogues
(e.g.
Meglitinide
,
Repaglinide
)
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