Pharm

First Generation Sulfonylurea

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First Generation Sulfonylurea, Tolbutamide, Tolazamide, Chlorpropamide, Acetohexamide

  • See Also
  1. Second Generation Sulfonylurea
  2. Oral Hypoglycemic Agents
  • Indications
  1. Replaced by Second Generation Sulfonylurea agents for the management of Type II Diabetes Mellitus
  • Preparations
  1. Acetohexamide (Dymelor)
    1. Dose: 500-750 mg qd or divided ($14)
  2. Chlorpropamide (Diabinese)
    1. Dose: 100-250 up to 750 mg qd/bid
    2. Antidiuretic effect (used in Diabetes Insipidus)
  3. Tolazamide (Tolinase)
    1. Dose: 250-500 mg PO qd or divided ($2.81)
  4. Tolbutamide (Orinase)
    1. Dose: 1000-2000mg qd or divided bid ($2.75)