Sex Hormone Binding Globulin


Sex Hormone Binding Globulin, SHBG, Sex Steroid Binding Globulin, SSBG

  • Physiology
  1. Glycoprotein produced primarily in liver, as well as sertoli cells (Testes), Uterus, placenta, brain
  2. Sex Hormone Binding Globulin (SHBG) binds 17 beta-hydroxysteriod Hormones: androgens (e.g. Testosterone) and Estrogen
  3. Transcortin, by contrast binds other steroid Hormones (Progesterone, Corticosteroids)
  • Interpretation
  • Normal Levels
  1. Male: 0.4 to 1.3 ug DHT/100 ml
  2. Female: 0.4 to 3.5 ug DHT/100 ml
  3. Pregnancy: 6.5 to 9.7 ug DHT/100 ml
  1. Oral Contraceptives
  2. Pregnancy
  3. Hyperthyroidism
  4. Cirrhosis
  5. Anorexa nervosa (or other longterm low calorie intake)
  6. Advancing age
    1. See Androgen Decline in the Aging Male