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Silodosin

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Silodosin, Rapaflo ( C2366232)

  • See Also
  1. Selective Alpha-1a Antagonist
  • Indications
  1. Benign Prostatic Hypertrophy
  2. Medical Expulsive Therapy for Ureteral Stone (Ureterolithiasis)
  • Contraindications
  1. Chronic Kidney Disease Stage 4 (GFR <30 ml/min)
  2. Severe liver disease (Child-Pugh Score 10 or more)
  • Dosing
  1. Take 8 mg daily with food
  2. Limit dose to 4 mg daily if GFR 30-50 ml/min
  • Adverse Effects
  1. See Selective Alpha-1a Antagonist
  2. Postural Hypotension (esp. when combined with Antihypertensives)
  3. Floppy Iris Syndrome
  4. Ejaculatory Dysfunction (class effect)
  • Drug Interactions
  1. Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
  2. Avoid Silodosin with strong P-Glycoprotein Inhibitors
  • Resources
  1. Silodosin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=96425d91-cfe1-477d-a130-b58c330ca8a3
  • References
  1. Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
    1. https://www.ncbi.nlm.nih.gov/books/NBK556066/