Pharm
Cialis
search
Cialis
, Tadalafil
See Also
PDE5 Inhibitor
Sildenafil
(
Viagra
)
Vardenafil (
Levitra
,
Staxyn
)
Indications
Psychogenic
Impotence
Neurogenic
Impotence
Vasculogenic
Impotence
Pharmacokinetics
Onset within 30 to 60 minutes
Duration as long as 36 hours
Contrast with 4 hours with
Viagra
Prolonged effect also leads to prolonged side effects
Dosing
Start 20 mg PO 1 hour before intercourse
Do not take more than once per 2 days
Most insurance limits to 6 per month
Indications to start with half dosing (10 mg)
Age over 65 years
Hepatic
Impairment
Renal
Impairment
Concurrent use of Cytochrome P3A4 inhibitor below
Contraindications
See
Phosphodiesterase Inhibitor
s (
PDE5 Inhibitor
s)
Men using nitrates (causes profound
Hypotension
)
Men using alpha blockers (e.g.
Hytrin
for BPH)
Mechanism
See
Phosphodiesterase Inhibitor
s (
PDE5 Inhibitor
)
Drug Interactions
See
Phosphodiesterase Inhibitor
s (
PDE5 Inhibitor
s)
Profound Vasodilitation and
Hypotension
with
Nitroglycerin
and alpha blockers such as
Prazosin
(Avoid)
Avoid nitrates within 48 hours of Tadalafil (Cialis)
Cytochrome P3A4 related interactions (
Cimetidine
, systemic
Antifungal
s,
Protease Inhibitor
s and
Macrolide
s
Adverse Effects
Viagra
(but most apply to the
PDE5 Inhibitor
Class as a whole)
See
Phosphodiesterase Inhibitor
s (
PDE5 Inhibitor
s)
Hypotensive effect for men on Nitrates (Avoid)
Vision
effects (color
Vision
,
Vision Loss
)
Sensorineural Hearing Loss
Mild
Headache
(21%)
References
2003 Med Lett Drug Ther 45:101-2 [PubMed]
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