Bone Turnover Biochemical Marker


Bone Turnover Biochemical Marker, Bone Remodeling Chemical Marker

  • Indications (used more as a research tool currently)
  1. Monitor peri-menopausal and postmenopausal bone loss
  2. Monitor treatment outcomes
  • Labs
  • Bone formation (Serum markers)
  1. Alkaline Phosphatase (total)
  2. Alkaline Phosphatase (skeletal isoenzymes)
  3. Procollagen-I Extension peptide
  4. Osteocalcin
  • Labs
  • Bone resorption (most are urine markers)
  1. Urine Calcium
  2. Urine hydroxyproline
  3. Serum type I Collagen breakdown product (serum CTX)
  4. Collagen cross-link fragments (first to be hydrolyzed)
    1. Urine Total pyridinoline
    2. Urine Free deoxypyridinoline
    3. Urine N-Telopeptide (n-terminus of Collagen fibril)
    4. Urine C-Telopeptide (c-terminus of Collagen fibril)