Edema

Idiopathic Cyclic Edema

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Idiopathic Cyclic Edema, Idiopathic Edema

  • Associated Conditions
  1. Premenstrual Syndrome
  • Epidemiology
  1. Affects young women most commonly
  • Pathophysiology
  1. No underlying systemic cause
  2. Related factors
    1. Increased capillary permeability
    2. Renin-Angiotensin-Aldosterone activation
  • Associated conditions
  1. Obesity
  2. Diabetes Mellitus
  3. Hypothyroidism
  • Signs
  1. No association with Menstrual Cycle
  2. Orthostatic Edema
    1. Water retention while upright
    2. Diuresis while supine
    3. Body weight increases >2 kg with edema
  • Differential Diagnosis
  • Estrogen stimulated edema
  1. Increased Estrogen with Sodium and water retention
  2. Cyclic edema related to Menses
    1. Weight gain on edematous days: 1.5 to 2.5 kg
    2. Lower extremity Pitting Edema
  3. Diuresis follows Menses
    1. Orthostasis may occur with diuresis
  • Management
  1. Avoid Diuretics (worsens edema)
  2. Restrict salt intake
  3. Consider ACE Inhibitor
  • References
  1. Brenner and Rector (2000) Kidney, Saunders, p. 845-6