Pharm

Lurasidone

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Lurasidone, Latuda

  • See Also
  1. Atypical Antipsychotic
  2. Psychosis
  • Indications
  1. Schizophrenia
  2. Bipolar Disorder
  1. Adult with normal hepatic and Renal Function
    1. Start: 40 mg orally daily with food
    2. Typical maintenance dose: 40-160 mg orally daily
    3. Maximum: 160 mg/day
  2. Adult with Moderate to severe hepatic or Renal Function (or strong CYP3A4 Inhibitor)
    1. Start: 20 mg orally daily with food
    2. Maximum: 80 mg/day (40 mg/day if severe hepatic insufficiency)
  3. Child (ages 13 to 17 years old)
    1. Start: 40 mg orally daily with food
    2. Typical maintenance dose: 40-80 mg orally daily
    3. Maximum: 80 mg/day
  1. Start: 20 mg orally daily with food
  2. Typical maintenance dose: 20 to 60 mg orally daily
  3. Maximum: 120 mg/day (no additional benefit of doses >60 mg)
  • Adverse Effects
  1. Significant CNS depression in Overdose
  2. Hyperlipidemia
  3. Diabetes Mellitus and Hyperglycemia (low risk)
  4. Parkinsonism
  5. Somnolence
  6. Nausea
  7. Extrapyramidal Side Effects (moderate risk)
  • Safety
  1. Unknown safety in pregnancy and Lactation
  • Drug Interactions
  1. Metabolized by CYP3A4
  • Resources
  1. Lurasidone (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=afad3051-9df2-4c54-9684-e8262a133af8
  • References
  1. (2016) Med Lett Drugs Ther 58(1510): 160-5
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 42-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia