- See NSAID
- Specific FDA-approved Diclofenac Indications
- Osteoarthritis
- Rheumatoid Arthritis
- Ankylosing Spondylitis
- Primary Dysmenorrhea
- Musculoskeletal Pain
- Migraine Headache (Cambia)
- See NSAID
- Other NSAIDs are preferred over Diclofenac
- Diclofenac has more adverse effects than other NSAIDs
- Cardiovascular Risk (similar to vioxx)
- Hepatotoxicity risk
- Increased GI toxicity risk
- References
- (2013) Presc Lett 20(7):42
- Oral
- Diclofenac Potassium (Voltaren, Cataflam)
- Diclofenac XR (Voltaren XR)
- Dose: 100 mg orally daily (up to twice daily)
- Diclofenac Powder (Cambia)
- Dissolve 50 mg packet in 30 to 60 ml water for Migraine Headache
- Arthrotec (50 mg Diclofenac with 200 mcg Misoprostol)
- Dose: 50/200 mg orally three times daily
- In addition to pregnancy-related NSAID contraindications, Misoprostol is also contraindicated in pregnancy
- Misoprostol may be associated with Diarrhea and Abdominal Pain
- Zorvolex 18 or 35 mg orally every 8 hours
- Topical
- Precautions
- Apply gel or patch only to unbroken skin
- Wash hands after applying gel or patch and avoid eye contact with product
- Do not wear patch while showering or bathing
- Diclofenac Gel (Pennsaid)
- Apply 2 gram dose to hands, 4 gram dose to knees
- Enclosed Card indicates 2 gram and 4 gram doses
- Flector Patch
- Applied to most painful area every 12 hours
- Licart Patch
- Applied to most painful area daily
- Precautions
- See NSAID
- Hepatotoxicity
- Monitor Liver Function Tests at baseline, 4 and 8 weeks after starting, then periodically
- Diclofenac Sodium (DailyMed)
- Diclofenac Delayed Release (DailyMed)
- Diclofenac XR (DailyMed)
- Diclofenac Topical Solution (DailyMed)