- Tropane alkaloid derived from Hyoscyamus niger and Atropa belladonna, plants in the nightshade family (Solanaceae)
- Chemical structure is similar to Acetylcholine and blocks Acetylcholine activity at Muscarinic Receptors
- Postganglionic Cholinergic nerves
- Smooth Muscle receptors
- Effects
- Ocular (Mydriasis, cycloplegia)
- Decreases Saliva secretion
- Decreases gastric acid secretion
- Decreases gastrointestinal motility
- Antiemetic properties
- Dosing
-
Adults (and children over age 12 years old)
-
Motion Sickness
- Apply Scopolamine patch patch (disc) behind ear starting 4 hours before travel, and may replace every 72 hours
- Prevention of post-operative Nausea or Vomiting
- Apply Scopolamine patch patch (disc) behind ear starting 4 hours before surgery, and remove 24 hours after surgery
- Perioperative nausea Vomiting (or prevention)
- Scopolamine 6 mcg/kg/dose IM/IV/SQ up to 0.3 mg/dose (may be repeated in 6 to 8 hours)
- Pregnancy Category C
- Safe in Lactation
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 46-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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