Pharm
Galantamine
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Galantamine
, Reminyl, Razadyne
See Also
Acetylcholinesterase Inhibitor
Dementia
Dementia Management
Rivastigmine
(
Exelon
)
Donepezil
(
Aricept
)
Indication
Alzheimer's Disease
related
Dementia
Mechanism
Acetylcholinesterase Inhibitor
Acts also at
Nicotinic Receptor
s
Derived from Daffodil bulbs
Pharmacokinetics
Half-Life
: 7 hours in elderly patients
Metabolized by liver enzymes:
CYP2D6
and
CYP3A4
Dosing
May require concurrent
Antiemetic
use
Immediate Release
Start: 4 mg orally twice daily with breakfast and dinner for 4 weeks
Maintenance: 8 mg orally twice daily for at least 4 weeks
Consider increase to 12 mg orally twice daily if indicated
Extended Release
Start: 8 mg orally daily for 4 weeks
Maintenance: 16 mg orally daily for at least 4 weeks
Consider increase to 24 mg orally daily if indicated
Adverse Effects
See
Acetylcholinesterase Inhibitor
Bradycardia
has also been reported with Galantamine
Efficacy
Moderately preserved cognitive function for >6 months
References
Raskind (2000) Neurology 54:2261 [PubMed]
Tariot (2000) Neurology 54:2269 [PubMed]
References
(2001) Med Lett Drugs Ther 43(1107):53-4 [PubMed]
Epperly (2017) Am Fam Physician 95(12): 771-8 [PubMed]
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