Pharm

Dihydroergotamine

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Dihydroergotamine, DHE-45

  • Indications
  1. Migraine Abortive Management
  • Dosing
  1. Parenteral
    1. Initial: 1 mg SC/IM/IV over 3-4 minutes
    2. Repeat: May repeat every 1 hour
    3. Maximum: 3 mg/day, 6 mg/week, 20 mg/month
  2. Intranasal Dihydroergotamine (Migranal)
  • Advantages
  1. Weaker Vasoconstrictor (less Side Effects)
  2. No Rebound Headache
  • Adverse Effects
  1. Retroperitoneal fibrosis