Pharm

Methysergide

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Methysergide, Sansert

  • See Also
  1. Migraine Prophylaxis
  • Indications
  1. Last line drug for Migraine Prophylaxis
  2. Use only with Neurology Consultation (due to toxicity)
  3. Rarely used in modern U.S. Migraine Management (largely replaced by other agents)
  • Mechanism
  1. Serotonin Antagonist (partial Agonist activity)
  • Dosing
  1. Sansert 4-8 mg PO qd
  2. Drug holiday for 4 weeks every 6 months
  • Adverse Effects
  1. Retroperitoneal fibrosis
  2. Weight gain
  3. Edema