- Syphilis
- Sexually Transmitted Disease
- Primary Syphilis
- Secondary Syphilis
- Latent Syphilis
- Tertiary Syphilis
- Syphilitic Gumma
- Cardiovascular Syphilis
- Neurosyphilis
- Syphilis Testing
- Genital Ulcer
- Untreated Latent Syphilis progresses to Tertiary Syphilis in one third of patients
- Occurs years to decades afer initial untreated Syphilis infection
- Low-level Syphilis infection with strong immune response
- Late benign Syphilis (50% of Tertiary Syphilis cases)
-
Cardiovascular Syphilis
- Typically involves Great Vessels (especially ascending aortitis)
-
Thoracic Aortic Aneurysm (including ascending aortic aneurysm)
- Proximal involvement may result in aortic valve insufficiency or Coronary Artery Disease
-
Neurosyphilis (Occurs in 10% of untreated Syphilis)
- Treponemal penetration of the blood brain barrier
- Tabes Dorsalis (Peripheral Neuropathy)
- Intracranial gummata (appear as CNS Mass)
- Meningitis
- Dementia
- See Syphilis Testing
- See Syphilis
- See Neurosyphilis
- Thoracic Aortic Aneurysm (from ascending aortitis)
- Neurosyphilis complications
- Kirk, McHugh and Parnell (2023) Crit Dec Emerg Med 37(8): 23-9
- Mattel (2012) Am Fam Physician 86(5): 433-40 [PubMed]
- Ricco (2020) Am Fam Physician 102(2): 91-8 [PubMed]