Pharm

Sofosbuvir

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Sofosbuvir, Sovaldi

  • See Also
  1. Sofosbuvir Ledipasvir
  2. Sofosbuvir Velpatasvir
  3. Sofosbuvir Velpatasvir Voxilaprevir
  4. Hepatitis C Antiviral Regimen
  5. Hepatitis C
  • Precautions
  1. See Hepatitis C Antiviral Regimen
  • Indications
  1. See Hepatitis C Antiviral Regimen
  2. Combined with various other agents used in every Hepatitis C virus Genotype
    1. Sofosbuvir is not typically used as HCV monotherapy
    2. Sofosbuvir Ledipasvir (Harvoni)
    3. Sofosbuvir Velpatasvir (Epclusa)
    4. Sofosbuvir Velpatasvir Voxilaprevir (Vosevi)
    5. Sofosbuvir with Ribavirin
      1. Older regimens that have been replaced by other combinations
  • Contraindications
  1. See Hepatitis C Antiviral Regimen
  • Mechanism
  1. Sofosbuvir is a NS5B Polymerase Inhibitor (...buvirs)
    1. Blocks RNA Polymerase, resulting in inhibition of viral replication
  • Evaluation
  1. See Hepatitis C Antiviral Regimen for Pre and post-treatment protocols
  • Adverse Effects
  1. See Hepatitis C Antiviral Regimen
  2. Headache
  3. Anemia
  4. Fatigue
  5. Nausea
  • Drug Interactions
  1. See Hepatitis C Antiviral Regimen
  2. Fewest Drug Interactions of the anti-HCV agents
  3. Reacts with potent P-Glycoprotein Inducers that lower Sofosbuvir drug levels (and its efficacy)
    1. Carbamazepine
    2. Rifampin
    3. Oxcarbazepine
    4. Phenobarbital
    5. Phenytoin
    6. Rifabutin
    7. Rifampin
    8. Rifapentine
    9. St. Johns Wort
    10. Tipranavir/r
  4. Amiodarone
    1. Causes severe Bradycardia resulting in Cardiac Arrest and pacer placement
  5. Safe Drugs
    1. No significant CYP450 interactions
    2. Does not interact with Statins
  • Monitoring
  1. See Hepatitis C Antiviral Regimen
  • Resources
  1. Sovaldi (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=80beab2c-396e-4a37-a4dc-40fdb62859cf
  • References
  1. (2023) Presc Lett, Hepatitis C Treatment Overview, Resource #390902
  2. (2014) Presc Lett 21(2): 8-9