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Sargramostim

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Sargramostim, Granulocyte Macrophage Colony Stimulating Factor, GM-CSF, Leukine

  • See Also
  1. Filgrastim
  2. Pegfilgrastim
  • Indications
  1. Bone Marrow Transplant
  2. Acute Radiation Syndrome
  • Mechanism
  1. Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF)
    1. Endogenous Cytokine encoded by human CSF-2 Gene
    2. Modulates the production and differentiation of Granulocyte, Macrophage, Eosinophil progenitors
    3. Also stimulates additional immune function
      1. Promotes Antigen Presentation
      2. Up-regulates Antibody-dependent cellular cytotoxicity (ADCC)
      3. Increases Interleukin-2-mediated Lymphokine-activated killer cell function
      4. Augments host antitumoral Immunity
  2. Sargramostim
    1. Recombinant, synthetic agent chemically identical to endogenous human GM-CSF (except Leucine substitution at 23)
    2. Similar activity to endogenous GM-CSF
  • Dosing
  1. See other references
  • Adverse Effects
  1. Hypersensitivity Reaction or Infusion Reaction
  2. Capillary Leak Syndrome
  3. Supraventricular Arrhythmias
    1. Increased risk in patients with history of Cardiac Arrhythmia
  • Safety
  1. Avoid Benzyl Alcohol containing solutions in pregnancy, Lactation and infants (risk of gaping syndrome)
  2. Unknown safety in pregnancy
  3. Unknown safety in Lactation
  • Resources
  1. Sargramostim (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb9a3820-f31a-4dd9-bef4-97094c01a398