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Chemotherapy-Induced Neutropenia

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Chemotherapy-Induced Neutropenia

  • See Also
  1. Drug-Induced Neutropenia
  2. Neutropenia
  3. Neutropenia Causes
  4. Neutropenic Fever
  • Findings
  1. Neutropenia onset 1 week after Chemotherapy (up to 6 weeks in some cases)
  2. Neutropenia duration following Chemotherapy
    1. Solid tumors: 7 days
    2. Hematologic Cancers: 14 days
  • Causes
  1. See Alkylating Agents
  2. See Antimetabolite Chemotherapy
  3. Anthracyclines (e.g. Doxorubicin, Daunorubicin)
  4. Taxanes (e.g. Paclitaxel, Docetaxel)
  5. Topoisomerase Inhibitors (Etoposide)
  6. Platinum Chemotherapy (e.g. Cisplatin)
  7. Gemcitabine (Gemzar)
  8. Vinorelbine (Navelbine)
  • Management
  1. Granulocyte Colony Stimulating Factor (G-CSF)
    1. Filgrastim (Neupogen)
    2. Pegfilgrastim (Neulasta)
    3. Sargramostim
  2. Primary Antibiotic prophylaxis is high risk patients
    1. Includes patients with >=20% risk of Febrile Neutropenia
  • Complications
  1. Neutropenic Fever
  • References
  1. Kim (2025) Am Fam Physician 112(6): 618-28 [PubMed]