Lab

Total Iron Binding Capacity

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Total Iron Binding Capacity, TIBC

  • Measurement
  1. Transferrin carries 2 iron atoms per molecule
  2. Transferrin is normally 30% bound to iron
  3. TIBC reflects a measurement of serum Transferrin
    1. Measured by saturating all available binding sites
  • Interpretation
  • Normal
  1. Range: 250-460 ug/dl
  • Interpretation
  • Increased TIBC
  1. Iron Deficiency Anemia
  2. Third trimester Pregnancy
  3. Polycythemia Vera
  • Interpretation
  • Decreased TIBC
  1. Anemia of Chronic Disease
  2. Hemolytic Anemia
  3. Hemochromatosis
  4. Chronic Liver Disease or Cirrhosis
  5. Hypoproteinemia
  6. Malnutrition
  7. Pernicious Anemia
  8. Sickle Cell Anemia