• Background
  1. Variants below as seen on Peripheral Smear
  • Causes
  • Toxic granulation of Neutrophils and Metamyelocytes
  • Causes
  • Atypical lymphocytes
  1. Characteristics
    1. Larger Lymphocytes with more cytoplasm
    2. Nuclei contain nucleoli
  2. Causes: Viral Infections
    1. Epstein Barr Virus (EBV, Mononucleosis)
    2. Cytomegalovirus (CMV)
    3. COVID-19
    4. HIV Infection
  • Causes
  • Giant cytoplasmic granules
  • Causes
  • Bilobed Neutrophils
  1. Pelger-Huet anomaly
  • Causes
  • Hypersegmented Neutrophils
  • Causes
  • Myeloblasts, Promyelocytes, Myelocytes
  1. Acute Myeloblastic Leukemia
  2. Acute promyelocytic Leukemia
  3. Chronic myelocytic Leukemia
  4. Myelofibrosis
  5. Polycythemia Vera
  1. T-gamma lymphoproliferative disease
    1. Natural Killer Cells
  • Plasmablasts