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Leukocyte Morphology on Peripheral Smear

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Leukocyte Morphology on Peripheral Smear, Leukocyte Morphology, White blood Cell morphology, Hypersegmented Neutrophil, Bilobed Neutrophil, Atypical lymphocyte, Toxic granulation, Lymphoblast, Plasmablast, Myeloblast, Promyelocyte, Myelocyte

  • See Also
  1. Bone Marrow Exam
  2. Leukocyte
  • Background
  1. Variants below as seen on Peripheral Smear
  • Causes
  • Toxic granulation of Neutrophils and Metamyelocytes
  1. Bacterial Infections
  • Causes
  • Atypical lymphocytes
  1. Characteristics
    1. Larger Lymphocytes with more cytoplasm
    2. Nuclei contain nucleoli
  2. Causes: Viral Infections
    1. Epstein Barr Virus (EBV, Mononucleosis)
    2. Cytomegalovirus (CMV)
    3. COVID-19
    4. HIV Infection
  • Causes
  • Giant cytoplasmic granules
  1. Chediak-Higashi Syndrome
  • Causes
  • Bilobed Neutrophils
  1. Pelger-Huet anomaly
  • Causes
  • Hypersegmented Neutrophils
  1. Pernicious Anemia (Vitamin B12 Deficiency)
  2. Folate Deficiency
  3. Myeloproliferative disease
  • Causes
  • Myeloblasts, Promyelocytes, Myelocytes
  1. Acute Myeloblastic Leukemia
  2. Acute promyelocytic Leukemia
  3. Chronic myelocytic Leukemia
  4. Myelofibrosis
  5. Polycythemia Vera
  1. T-gamma lymphoproliferative disease
    1. Natural Killer Cells
  • Causes
  • Lymphoblasts
  1. Acute Lymphoblastic Leukemia
  2. Prolymphocytic Leukemia
  3. Malignant Lymphoma
  4. Chronic Lymphocytic Leukemia
  5. Infectious Mononucleosis
  • Plasmablasts
  1. Multiple Myeloma