Pharm

Doravirine

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Doravirine, Pifeltro

  • See Also
  1. Non-Nucleoside Reverse Transcriptase Inhibitor
  2. Anti-Retroviral Therapy
  • Indications
  1. HIV Infection (part of combination therapy)
    1. High risk of induced HIV resistance
    2. Never use NNRTIs as monotherapy in HIV Infection
  • Mechanism
  1. See Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
  2. Second generation NNRTI
  • Dosing
  1. HIV Infection in Adult (or child weight >35 kg), in combination with other Antiretrovirals
    1. Take 100 mg orally daily
  • Adverse Effects
  1. See Non-Nucleoside Reverse Transcriptase Inhibitor
  • Safety
  1. Avoid in Lactation
  2. Unknown safety in pregnancy (registry exists)
  • Drug Interactions
  1. Rifabutin
    1. Increase Doravirine frequency to 100 mg orally twice daily
  2. CYP3A4 Inducers
    1. Avoid strong CYP3A4 Inducers with 4 weeks of Doravirine
    2. Examples include Carbamazepine, Phenobarbital, Phenytoin, Rifampin
  3. NNRTIs
    1. Do not coadminister with other NNRTIs including Efavirenz, Etravirine, Nevirapine
  • Resources
  1. Doravirine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=76ce1f00-28c0-4314-bd2c-d473fe3d0970