Doravirine, Pifeltro

  • Indications
  1. HIV Infection (part of combination therapy)
    1. High risk of induced HIV resistance
    2. Never use NNRTIs as monotherapy in HIV Infection
  • Mechanism
  • Dosing
  1. HIV Infection in Adult (or child weight >35 kg), in combination with other Antiretrovirals
    1. Take 100 mg orally daily
  • Safety
  1. Avoid in Lactation
  2. Unknown safety in pregnancy (registry exists)
  • Drug Interactions
  1. Rifabutin
    1. Increase Doravirine frequency to 100 mg orally twice daily
  2. CYP3A4 Inducers
    1. Avoid strong CYP3A4 Inducers with 4 weeks of Doravirine
    2. Examples include Carbamazepine, Phenobarbital, Phenytoin, Rifampin
  3. NNRTIs
    1. Do not coadminister with other NNRTIs including Efavirenz, Etravirine, Nevirapine