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Etravirine

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Etravirine, Intelence

  • See Also
  1. Anti-Retroviral Therapy
  2. Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
    1. Second generation agent
  • Indications
  1. Anti-Retroviral Therapy experienced patients
  2. Resistance (especially K103N) to first-generation NNRTI (Efavirenz or Nevirapine)
  • Class
  1. Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
  • Adverse Effects
  1. See NNRTI for class related adverse effects
  2. Rash (20% of patients)
    1. Stop the agent and do not rechallenge
    2. Higher risk in women (30%) than men (18%)
    3. Risk of serious reactions (1-2%)
      1. Stevens-Johnson Syndrome
      2. Toxic Epidermal Necrolysis
      3. Eythema multiforme
  3. Nausea
  4. Peripheral Neuropathy
  5. Hypertension
  6. Hepatotoxicity
  7. Hyperlipidemia
  • Monitoring
  1. Liver Function Tests
  2. Lipid profile
  • References
  1. (2008) Med Lett Drugs Ther 50(1288): 47-8 [PubMed]
  2. (1998) Med Lett Drugs Ther 40(1041):115 [PubMed]
  3. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]