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Progestin Activity

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Progestin Activity, Progestational Activity, Progesterone Potency

  • See Also
  1. Oral Contraceptive
  2. Progestin
  • General
  1. Depends on Estrogen stimulating Progestin receptors
  • Characteristics
  1. Conditions associated with High Progestin Activity
    1. Increased Appetite
    2. Major Depression
  2. Conditions associated with Low Progestin Activity
    1. Mid-cycle spotting (days 10-21)
    2. Heavy Menses
    3. Dysmenorrhea
  • Preparations
  • Progestins with most potent Progestational Activity
  1. Progestin Activity based on Norethindrone mg/day
  2. Gestodene (12.6)
  3. Desogestrel (9.0)
  4. Levonorgestrel (5.3)
  5. dl-Norgestrel (2.6)
  6. Norethindrone (1.0) - Low reference
  1. Progestin Activity based on Norethindrone mg/day
  2. Ortho-Cyclen (Norgestimate): 0.3
  3. Ortho Tri-Cyclen (Norgestimate): 0.3
  4. Alesse (Levonorgestrel): 0.5
  5. Triphasil (Levonorgestrel): 0.5
  6. Modicon (Norethindrone): 0.5
  7. Nordette (Levonorgestrel): 0.8
  8. Lo-Ovral (Norgestrel): 0.8
  9. Ortho-Novum 777 (Norethindrone): 0.8
  10. Ortho-Novum 1/35 (Norethindrone): 1.0
  11. Ortho-Cept or Desogen (Desogestrel): 1.0
  12. Estrostep (Norethindrone Acetate): 1.2
  13. Loestrin 1/20 (Norethindrone Acetate): 1.4
  14. Demulen 1/35 (Ethynodiol Diacetate): 1.4
  15. Loestrin 1.5/30 (Norethindrone Acetate): 1.7
  • References
  1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
  2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
  3. Dickey (1998) Managing Contraceptive Pill Patients