- FDA Approved
-
Ovulation Induction (Female Infertility due to Anovulation)
- Chorionic Gonadotropin (Recombinant HCG, Pregnyl, Novarel)
- Choriogonadotropin Alfa (Ovidrel)
- Prepubertal Cryptorchidism (age 4 to 9 years, may induce testicular descent)
- Chorionic Gonadotropin (HCG, Pregnyl, Novarel)
-
Hypogonadotropic Hypogonadism in males (pituitary deficiency related)
- Chorionic Gonadotropin (HCG, Pregnyl, Novarel)
- Precocious Puberty
- Prostate Cancer (or other androgen dependent cancers)
- Primary ovarian failure
- Uncontrolled Thyroid or adrenal dysfunction
- Pituitary Lesions
-
Human Chorionic Gonadotropin (HCG)
- Prevents corpus luteum from involuting during pregnancy
- Allows for continued increase of Estrogen and Progesterone
- Stimulates Testosterone production in the male fetus Testes
- Prevents corpus luteum from involuting during pregnancy
- HCG is a GlycoproteinHormone with subunits a and b
- Beta subunit (bHCG) is unique to HCG
- HCG shares the same alpha subunit with other Hormones
- Chorionic Gonadotropin (HCG, Pregnyl, Novarel)
- Purified HCG extract from the urine of pregnant women
- Available in vials of 10,000 USP units of HCG that require reconstitution
- Administered IM
- Choriogonadotropin Alfa (Recombinant HCG, Ovidrel)
- Recombinant HCG product
- Available in a preFilled Syringe containing 250 mcg
- Administered subcutaneously
- See other references for specific Infertility regimens
- Use is typically limited to Infertility specialists
- Typically dosed after an initial 9-12 day course of Recombinant Follicle Stimulating Hormone
- Ovarian Hyperstimulation
- Fluid third spacing (Ascites, Pleural Effusion, edema)
- Ruptured Ovarian Cyst
- Ovarian Torsion
- Multiple Gestation
- Arterial Thromboembolism
- Anaphylaxis (urine-derived HCG)
- Irritability
- Headache
- Gynecomastia
- Unknown safety in Lactation
- Contraindicated in pregnancy
- Associated with congenital abnormalities when used AFTER pregnancy is established
- No known increased risk of congenital abnormalities when used to induce Ovulation for Infertility
- Chorionic Gonadotropin (DailyMed)
- Choriogonadotropin Alfa - Ovidrel (DailyMed)