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Magnesium Citrate

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Magnesium Citrate, Citroma

  • See Also
  1. Magnesium Hydroxide
  2. Osmotic Laxative
  3. Laxative
  4. Constipation
  5. Functional Constipation
  6. Pediatric Constipation
  • Indications
  1. Functional Constipation
  2. Colonoscopy Preparation
  • Contraindications
  1. Renal Failure
  • Mechanism
  1. Magnesium salt Osmotic Laxatives
  2. Poorly absorbed, hyperosmolar agents
  • Precautions
  1. Avoid longterm use due to Electrolyte loss risk
    1. These agents are typically used once as part of a bowel regimen
  • Dosing
  1. General
    1. Patients should have immediate access to toilet for at least 6 hours after taking Magnesium Citrate
  2. Adult (and age >12 years)
    1. Full dose: Take 8 to 10 ounces (240 to 300 ml, 1 bottle) orally divided once or twice for 1 day
    2. Half dose: Take 5 oz (150 ml, 1/2 bottle) orally once
  3. Child (age 2 to 12 years)
    1. Age 2 to 5 years: 1 to 3 ml/kg/day divided once or twice for 1 day
    2. Age 6 to 11 years: 4 ml/kg (up to 200 ml) OR 100 to 150 ml divided once or twice for 1 day
  • Pharmacokinetics
  1. Absorption of up to 30% of Magnesium Citrate dose
  2. Rapid onset within 3 hours
  3. Patients should have immediate access to toilet for at least 6 hours after taking Magnesium Citrate
  • Adverse Effects
  1. Hypermagnesemia (in patients with Renal Failure)
  • Safety
  1. Pregnancy Category B
  2. Unknown Safety in Lactation
  • Drug Interactions
  1. Decreases absorption of other drugs
    1. Phenytoin
    2. Ciprofloxacin
    3. Benzodiazepines
    4. Glyburide
  2. CNS Depressants
    1. Magnesium Citrate may have additive effects with increased CNS depression
  • Resources
  1. Magnesium Citrate (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cff04fd1-8404-4e0f-9220-d4846d652839
  • References
  1. (2023) Management of Constipation, Presc Lett, #390108
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia