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Medication Causes of Hyperglycemia

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Medication Causes of Hyperglycemia, Medications Affecting Glucose Control, Medications Predisposing to Diabetes Mellitus

  • See Also
  1. Hyperglycemia Causes
  • Causes
  • Medications Predisposing to Diabetes Mellitus (with longterm use)
  1. Systemic Corticosteroids (e.g. Prednisone)
    1. Decreases Glucose uptake
  2. Thiazide Diuretics (e.g. Hydrochlorothiazide, Chlorthalidone)
    1. Inhibits Insulin release
    2. Hypokalemia mediated decreased Glucose control
    3. Risk of Diabetes Mellitus: 1 per 125 (for those using Thiazide Diuretic for at least 5 years)
      1. Risk increases to 1 in 17 if Impaired Glucose Tolerance is already present
  3. Statins (e.g. Atorvastatin, Simvastatin, Rosuvastatin)
    1. Decreases skeletal muscle Insulin sensitivity
    2. Risk of Diabetes Mellitus: 1 per 1000 (for those on Statin for 1 year)
  4. Atypical Antipsychotics (e.g. Clozapine, Zyprexa)
    1. Significant weight gain (via increased hunger)
  5. References
    1. (2014) Presc Lett 21(5): 28
  • Causes
  • Miscellaneous medications
  1. Azathioprine
  2. Chemotherapeutic medications
  3. Cimetidine (Tagamet)
  4. Morphine
  5. Methadone
  6. Anesthetics
  7. Tranquilizers
  • Causes
  • Cardiovascular medications
  1. Potassium-wasting Diuretics (suppress Insulin secretion)
    1. Thiazide Diuretics (Hydrochlorothiazide, Chlorthalidone)
    2. Loop Diuretics (e.g. Furosemide or Lasix)
  2. Calcium Channel Blockers
  3. Epinephrine
  4. Propranolol
  5. Diazoxide (Hyperstat)
  • Causes
  • Neurologic medications
  1. Phenytoin (Dilantin, Suppresses Insulin secretion)
  1. Duloxetine (Cymbalta)
  2. Atypical Antipsychotics
    1. Clozapine (Clozaril) - higher risk
    2. Olanzapine (Zyprexa) - higher risk
    3. Risperidone (Risperdal)
    4. Quetiapine (Seroquel)
    5. Chlorpromazine (Thorazine)
  • Causes
  • Endocrine medications
  1. Glucocorticoids or Corticosteroids (Antagonize Insulin action)
  2. Thyroxine
  3. ACTH
  • Causes
  • Infectious Disease medications
  1. Interferon
  2. Pentamidine
  3. Protease Inhibitors
  1. Cocaine
  2. Alcohol
  • References
  1. Stoner (2017) Am Fam Physician 96(11):729-36 [PubMed]
  2. Stoner (2005) Am Fam Physician 71:1723-30 [PubMed]