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Hourly Subcutaneous Insulin

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Hourly Subcutaneous Insulin, Hourly Subcutaneous Insulin Aspart, Hourly Subcutaneous Insulin Lispro

  • See Also
  1. Insulin Infusion
  2. Diabetic Ketoacidosis
  • Indications
  1. Diabetic Ketoacidosis in adults
  1. Initial dose: 0.3 units/kg
  2. Next: 0.1 units/kg/hour until Hyperglycemia corrects
  3. Next: 0.05 units/kg/hour until DKA resolves
  4. Coadminister fluids as per Diabetic Ketoacidosis
  5. Discontinue hourly dosing when Glucose 150-200
  • Precautions
  1. Correct Hypokalemia prior to Insulin Dosing
  2. Fluid administration is central to DKA treatment
  • Monitoring
  1. Blood Glucose every 30 minutes to 1 hour
  • Advantage over Insulin Infusion
  1. May be monitored on regular medical ward (non-ICU)
  2. Reduced cost by 39% compared with infusion
  • Safety and efficacy
  1. As effective and safe as Insulin Infusion
  • References
  1. Umpierrez (2004) Am J Med 117:291-6 [PubMed]
  2. Karoli (2011) Indian J Pharmacol 43(4): 398-401 [PubMed]