Pharm
Lindane
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Lindane
, Kwell, Organochlorine, Gamma Benzene Hexachloride
See Also
Pesticide
Precautions
Do not use in infants
Much greater risk of toxicity than with other agents
Percutaneous absorption 10-20 fold over
Permethrin
Serum levels are 40 fold higher than
Permethrin
CNS toxicity 2-4 fold over
Permethrin
Seizure
risk in epileptics and children
Mechanism
Organochlorine similar to DDT
Organochlorine Agents
Chlorobenzilate
Dicofol
Dienochlor
Endosulfan
Lindane
Indications
Scabies
Lice
Preparation
Lindane 1%
Shampoo
(60 ml)
Lindane 1% Lotion (60 ml)
Directions for use
Scabies
Apply lotion to skin from neck to toes
Wash off in 6 to 8 hours
Repeat application in 1 week
Lice
Apply
Shampoo
to dry hair
Massage into hair for 4 minutes before rinsing
Rinse thoroughly and comb with fine tooth comb
Repeat treatment in one week
Adverse Effects
Mechanism
Disrupts axonal
Sodium
and
Potassium
flow
Affects both central and
Peripheral Nerve
s
Higher toxicity in broken skin and young children
Effects: Neurotoxicity
Seizure
Headache
Paresthesia
s
Incoordination
Tremor
Management of toxicitiy
Skin Decontamination
ABC Management
Seizure
control with
Diazepam
Intravenous Fluid
s (D5W) with
Thiamine
References
Meinking (1996) Arch Dermatol 132:959-62 [PubMed]
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