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Skin Ulcer

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Skin Ulcer, Skin Erosion, Skin Ulceration, Skin and Subcutaneous Tissue Ulceration

  • See Also
  1. Pathergy
  • Definitions
  1. Skin Erosion
    1. Focal, superficial epidermal loss
    2. Heals without scarring
  2. Skin Ulceration
    1. Focal loss of Epidermis and Dermis
    2. Ulcers heal with scar formation
  • Differential Diagnosis
  • Erosion
  1. Dermatophyte infection or Candidiasis
  2. Eczematous Dermatitis
  3. Herpes Simplex Virus
  4. Intertrigo
  5. Excoriations (include Neurotic Excoriations)
  6. Aging Skin
  7. Toxic Epidermal Necrolysis
  8. Vesicles and Bullae
  • Differential Diagnosis
  • Ulceration
  1. See Oral Ulcer
  2. See Genital Ulcer
  3. External Skin Injury
    1. Skin Trauma
    2. Skin picking
    3. Envenomation (e.g. Brown Recluse Spider Bite)
    4. Decubitus Ulcer
  4. Bacterial Skin Infection
    1. Streptococcus (e.g. Ecthyma)
    2. Staphylococcus (e.g. Impetigo)
    3. Pseudomonas
    4. Treponema pallidum (Syphilis)
    5. Mycobacterium ulcerans (Buruli Ulcer)
    6. Haemophilus ducreyi (Chancroid)
    7. Cutaneous Mycobacterium tuberculosis
  5. Viral Skin Infections
    1. Herpes Simplex Virus Type 2
    2. Coxsachievirus
  6. Deep Fungal Skin Infections
    1. Coccidiomycosis
    2. Mucormycosis
    3. Sporotrichosis
    4. Aspergillosis
    5. Cryptococcosis
    6. Zygomycosis
    7. Penicillium marneffei
  7. Parasitic Skin Infections
    1. Leishmaniasis
    2. Amoebiasis
    3. Schistosomiasis
  8. Medium or Small Vessel Vasculitis
    1. Polyarteritis Nodosa
    2. Microangiopathic Vasculitis
    3. Granulomatosis with Polyangiitis (previously known as Wegener's Granulomatosis)
    4. Rheumatoid Arthritis
    5. Takayasu Arteritis
    6. Necrobiosis Lipoidica (associated with Diabetes Mellitus)
    7. Leukocytoclastic Vasculitis (secondary to infection)
  9. Vascular insufficiency
    1. Arterial Insufficiency
    2. Venous Stasis Ulcer
    3. Antiphospholipid Antibody Syndrome
    4. Type I Cryoglobulinemia
    5. Klippel-Trenaunay-Weber Syndrome
    6. Livdeoid Vasculopathy
  10. Skin Neoplasm
    1. Non-melanoma Skin Cancer (Basal Cell Skin Cancer, Squamous Cell Skin Cancer)
    2. Leukemia Cutis
    3. Langerhans Cell Histiocytosis
    4. Lymphoma
      1. Angiocentric T-Cell Lymphoma
      2. Anaplastic Large Cell T-Cell Lymphoma
      3. Mycosis Fungoides bullosa
  11. Medications
    1. Hydroxyurea
    2. Contact Dermatitis
    3. Superinfected Injection Drug Abuse
    4. Bromoderma
    5. Drug-induced Lupus
  12. Miscellaneous Causes
    1. Pyoderma Gangrenosum (Neutrophilic dematosis)
    2. Cutaneous Crohn's Disease
    3. Brown Recluse Spider Bite (Loxoscelism)
  • References
  1. Jhun and DeClerck in Herbert (2015) EM:Rap 15(8): 19-20
  2. Weenig (2002) N Engl J Med 347(18):1412-8 +PMID: 12409543 [PubMed]