Pharm

Metolazone

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Metolazone, Zaroxolyn

  • See Also
  1. Thiazide Diuretic
  • Indications
  1. Not typically used for Hypertension
  2. Diuretic Resistance in Edematous States
    1. Congestive Heart Failure
    2. Chronic Kidney Disease
  • Dosing
  • Edema (CHF, renal disease)
  1. Take 30 minutes before Loop Diuretic
  2. Start: 2.5 mg daily (esp. if combined with Loop Diuretic)
  3. Target: 5 to 10 mg orally daily
  4. Maximum: 10 mg/day in CHF (20 mg/day in renal disease)
  • Mechanism
  1. See Thiazide Diuretic
  • Pharmacokinetics
  1. Onset of activity within 1 hour
  2. Duration >24 hours
  • Adverse Effects
  1. See Thiazide Diuretic
  2. Monitor for Electrolyte disturbance (esp. when combined with Loop Diuretics)
  • Safety
  1. Unknown Safety in Lactation
  2. Pregnancy Category B
    1. Pregnancy Category D if used for Pregnancy Induced Hypertension
  • Resources
  • Metolazone (DailyMed)
  1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6639d111-eb21-4997-b964-f5c61bc088f2
  • References
  1. (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia