Pharm
Interleukin-1 Receptor Antagonist
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Interleukin-1 Receptor Antagonist
, Anti-IL6 Monoclonal Antibody, Anakinra, Kineret
Indications
Severe active
Rheumatoid Arthritis
refractory to
DMARDs
Contraindications
Chronic or acute infection
Concurrent use of TNF
Antagonist
s (infection risk)
Adalimumab
(
Humira
)
Etanercept
(
Enbrel
)
Infliximab
(
Remicade
)
Mechanism
Interleukin-1 Receptor Antagonist
Dosing
Adults: 100 mg SC qd with rotating injection sites
Cost
Vial of 100 mg/0.67 ml (7 doses): $260
Adverse Effects
Immunosuppression
Use caution in any patient prone to infection
Headache
Injection site inflammation
Gastrointestinal upset
Leukopenia
(including
Neutropenia
)
Monitoring
Serum Creatinine
Complete Blood Count
with
Neutrophil Count
Baseline, then
Monthly for 3 months, then
Quarterly
References
(2003) Lexicomp Drug Database
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