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Adalimumab

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Adalimumab, Humira, Abrilada, Amjevita, Cyltezo, Hulio, Hyrimoz, Yusimry

  • See Also
  1. Etanercept (Enbrel)
  2. Infliximab (Remicade)
  3. Monoclonal Antibody
  • Indications
  1. Severe active Rheumatoid Arthritis refractory to DMARDs
  2. Plaque Psoriasis
  3. Crohns Disease
  • Contraindications
  1. Chronic or acute infection
  2. Concurrent use of Interleukin-1 Receptor Antagonist
    1. Anakinra (Kineret)
  1. Human antitumor Necrosis Factor alpha
  2. Similar to Infliximab and Etanercept
  • Preparations
  1. Humira (Adalimumab)
    1. Original prototype drug with release in 2003 for Rheumatoid Arthritis, with expanding indications since
  2. Multiple biosimilar agents pending release in 2023
    1. Abrilada
    2. Amjevita
    3. Cyltezo
    4. Hulio
    5. Hyrimoz
    6. Yusimry
  • Dosing
  1. Every other week: 40 mg SC
  • Adverse Effects
  1. Immunosuppression
    1. Use caution in any patient prone to infection
  2. Headache
  3. Rash
  4. Hypertension
  5. Hyperlipidemia
  6. Injection site inflammation
  7. Gastrointestinal upset
  • Cost
  1. Two 40 mg vials: $1200 (in 2003)
  • References
  1. (2003) Lexi-Comp Drug Database