Antiphospholipid Antibody Test


Antiphospholipid Antibody Test, aPL Antibody, Antiphospholipid Antibodies, Antiphospholipid Antibody, Anticardiolipin Antibody Test, Anticardiolipin Antibody

  • Mechanism
  1. IgM, IgG, or IgA binding to cell-membrane constituents
  2. Measured by enzyme-linked immunosorbent assay
  • Indications
  • APL testing
  1. Connective Tissue Disease with clotting disorder
  2. Recurrent thrombosis without obvious cause
    1. See Hypercoagulability
  • Types
  • Antiphospholipid Antibodies
  1. Anticardiolipin Antibody (ACA)
  2. Lupus Anticoagulant
    1. Prolongs Partial Thromboplastin Time (PTT)
    2. Prolongs Russell viper venom time
  3. VDRL False Positive
  • Causes
  • APL elevations (>3 SD)